Jože Senica has been in the police force since 1994, when, after completing his secondary school studies, he began his career as a police officer at Dobova Police Station within the former Internal Affairs Administration in Krško. In 1997, he was transferred to Velenje Police Station. 

After completing his studies at the Administrative College in Ljubljana in 1998, he began his career as a criminal police officer in the Criminal Police Division of Celje Police Directorate, where he worked in the Juvenile Crime Group of the General Crime Section. In 2001, after completing his studies at the College of Police and Security Studies in Ljubljana, he was promoted to head of this group.

Between December 2003 and January 2005 he served in the EU Police Mission Proxima in Macedonia in the capacity of adviser on organised crime and counter-terrorism. 

Upon returning from the mission, Jože Senica became head of the Organised Crime Section of the Criminal Police Division of Celje Police Directorate, a position he held until October 2008, when he was promoted to head of the Criminal Police Division of Celje Police Directorate.

He received a master's degree at the Faculty of Criminal Justice and Security in 2011. Since 2008, he has been active as an instructor of criminal investigation.

He took up the position of Head of Celje Police Directorate on 1 Maj 2012. He successfully managed the third largest police directorate in Slovenia with about a thousand staff, six internal organisational units and eighteen police stations until 30 September 2018.

On 1 October 2018 he was appointed Deputy Director General of the Police and was in charge of operational, EU and international affairs. On 29 March 2021, Senica took up the position of Assistant Director General of the Police. One of his duties in this role is the development of a cooperation strategy of the Slovenian police within the EU and internationally. He is in charge of the Subgroup of the Ministry of the Interior and the Police for police cooperation within the EU. He is also Slovenia’s delegate to COSI, the Standing Committee on Operational Cooperation on Internal Security. In this role, he chaired the COSI Committee during Slovenia's Presidency of the Council of the EU in the second half of 2021.

Senica, who graduated from a prestigious FBI executive leadership programme in September 2023, is also Slovenia's representative on the Europol Management Board.

Since April 2018, he has served as the President of the Slovenian Section of the International Police Association, which has around 7 500 members. In October 2023, he was elected Secretary General of the International Police Association (IPA).